Man it's all about the edits homie. Resampling is key as well. What I like to do is sample the whole drum loop of the track Minus the kick drum. Then you can export that wav to Logic or ACID for more editing. From there you can re-arrange the main loop to give it more variation. The same can go for synth parts and FX chanegs too. You can resample them rather than trying to automate all of the changes.

For example if you want a reverse kick on just the end section of the kick sequence....

If using FLSTUDIO, clone the channel for the kick drum and copy the pattern originally made for the kick.

It will show you're kick pattern just as with the original loop. Then with the cloned channel, flip the sample into reverse. Place a step in the sequencer for the last step on the loop for the reverse kick. Remove the last kick from the regular pattern. Then just put the new piece into the arrangement where needed.

Now if you want to just have the synth sweep out or something, resample 1/4th of the 16 bar loop using the loop tool in FL. Then you will get just a snip of your synth. You then export it as wave and re-import it back into the project. Then load that snip into the sequencer on it's own pattern. It will already have your original FX applied then you can add delay or whatever it is you wish. I preffer delay myself because it gives it that fading out feeling with the delay.

I hope that my info is healpful and useful to you. If there is something not clear, just let me know.