For endorphin I get some nice results when I put the attack really high (fader up) and the release very low (fader down).

You will get some distortion if it's too low tho so if you get crackling.. ease up on it there.

If your sat. meter isn't pegged in red then you can go ahead and crank the lo and hi comp faders up a bit... if it still isn't pegged in red then crank the mix levels up too..
Now if it's still not pegged in red you can crank the de-comp/sat fader up a bit too.

The goal is to not have the signal stay in the red.
If it does then you need to back off a bit either input vol wise or with your settings.

These settings are what I use to make shit sound really thick and big.... there are obviously many uses for this sort of compressor tho.

Hope that helps ;)