They should have:
* mixture of BIG and little knobs (big ones for mostly tweaked functions)
* enough space for your fingers
* be small enough for transportation
* logically layed out
* plenty of visual feedback (proper labels, could be printed/vinyl cut... lcd screen and plenty of leds showing button/switch status)
* sequence position feedback (for example a counter that counts bars and beats up to a specified number. You can change amount it counts up to)
could keep going but it would get expensive :)