I don't think Shearer and Owen will work as a partnership, as we saw for England, but I don't think Henry and Owen would work either - 2 target men together doesn't work, you need one to play deep. Henry could do that, but it'd be a waste of his pace and power, if we signed someone like Owen it'd be as back up for Henry, which they wouldn't like - unless they could play in midfield too like Baptista.
Luque looks good though, if Souness see's sense he'll play him with Shearer or Owen, but he won't be able to keep them both happy. I suppose it's possible it could work if Shearer drops off to get a flick on, then maybe Owen goes out wide to cross for Shearer, bit of give and take, but I don't see it working as well as Shearer and Bellamy, even if it does work.