What I find to be more of a hassle is having to deal with plug ins, and maintaining any sort of "controller setup" where I don't have to use the mouse to manipulate the stuff. Your mindset and workflow about creating sounds and riffs is completely different when you are working all those buttons and knobs with both hands instead of clicking around bit by bit.
All my studio gear is what I drag out live to play with so I have to hook EVERYTHING up over and over after shows and it leads to new ideas about the actual layout of your studio when you have to rewire things. I've changed where things are located dozens of times and you start to get a better feel for an ergonomic placement of your gear and equipment around you which in the long run helps you write music more easily.