a sequence is just a loop of midi notes, there is no difference really.
I use both loops of my own audio and midi triggered vsti synths.
{...}
It`s so easy to edit midi on the fly, copy, merge it, change it, re-assign controllers, change the groove of an audio loop etc
Though that confuses me a bit - you've made the difference clear in the latter part - midi can be altered a lot more on the fly than audio.