this may seem obvious to some, but i notice that many dont really play around with hooking this up to that in reason...maybe because the vast web of cables intimidate people, i dotn know :)

but its really good to try out a lot of combinations..in the beginning it can seem frustrating that you have to create this and that effect for every sound, but its really worth it..but dont overdo it either of course, unless this is exactly what you want

but a thing i do every time is create a mixer for synth sounds, etc. and then a mixer for the drums alone...and a i almost always hook a reverb and a delay and compressor up as send effects on both mixers, but i think many do this though

and the tape effect on the new distortion is great , as mentioned, but many of the other effects can be pretty good too...especially i found the warp effect to be good with string type samples, it can really make it like nice distorted synth sounds

also, a thing that a lot of people dont know is that you can save your samples within your reason file, you can do this in file>song self contain settings...so you dont have to take all your samples with you, if you move it to another computer